The results of previously conducted human trials have indicated that Exsulin triggers at least a partial recovery of natural insulin secretion. Although at this stage of development it may not completely control the amount of circulating glucose, Exsulin does improve glucose homeostasis, which prevents the dramatic fluctuations that can lead to the main complications of diabetes: neuropathy, renal failure, blindness and heart disease. This new clinical trial aims to test a new formulation of Exsulin and to establish the best dosing schedule, as well as the most effective dosage.

In vitro experiments on human pancreatic tissue have shown that Exsulin acts on stem-like cells by causing them to differentiate into new insulin-producing beta cells, as well as the three other types of endocrine cells that make up the islets of Langerhans. In a healthy pancreas, these "islets," or small groups of cells, house all cells that produce glucagon, somatostatin, pancreatic polypeptide, as well as those that produce insulin.

"This means that Exsulin could help rebuild the islets' entire structure, restoring near-normal metabolic control-something that insulin injections alone cannot do," concluded Dr. Rosenberg.

Source: THE MONTREAL CHILDREN'S HOSPITAL

Source: MCGILL UNIVERSITY HEALTH CENTRE

Source: THE MONTREAL CHILDREN'S HOSPITAL FOUNDATION