Dr. Chain commented, "Dr. Cawthorne and I are pleased by the grant of a new patent in Europe relating to this novel approach. We predicted that some of the drugs now used in the treatment of diabetes may also help in the treatment and prevention of AD and other forms of memory loss. We are hopeful that drugs that improve glucose utilization in the brain could be used to treat memory loss in presymptomatic Alzheimer's disease or perhaps treat age-related memory loss." Dr. Chain continued: "Glucose is used by cells in the brain to make the energy needed for the cells to live, but glucose utilization may be impaired in the brains of older people and those suffering from senile dementia or other forms of memory loss.  There is growing evidence that defective brain glucose utilization results from resistance to the action of insulin. Insulin sensitizer drugs such as Rosiglitazone and Pioglitazone help brain cells properly use glucose. This approach has generated considerable interest in the pharmaceutical industry, as there is now compelling evidence from clinical trials supporting this theory."

Source : Intellect Neurosciences